ColdFusion 10 Update 11(http://helpx.adobe.com/coldfusion/kb/coldfusion-10-update-11.html) has been released which includes support for 64-bit COM interoperability, Microsoft SQL Server 2012 and MySQL 5.6 in addition to several important bug fixes.This update includes a fix for bug 3488063 - IIS 404 custom error handler URLs that are .CFM files do not consistently return entire document .
Though the wsconfig.jar(present in ColdFusion10\cfusion\runtime\lib,which is required for configuring connectors) has been modified for the above mentioned bug ,it is not required to re-install the connector in all the cases.
If you are on ColdFusion 10 Update 5 or later and are using IIS webserver,you must either re-install/reconfigure the connector or use the command line interface and run the '-upgrade' option.The '-upgrade' option upgrades existing configured connectors with newer modules from a newer wsconfig.jar file.
<cf_root>/runtime/bin/wsconfig.exe -ws iis -upgrade -site <site name/ID>
If you are on ColdFusion 10 Update 5 or later and are using Apache webserver , you don't need to re-install/reconfigure the connector as the fix was specific to IIS webserver and the Apache connector files remain the same.
If you are not on ColdFusion 10 Update 5 or later then you will have to re-install/reconfigure the connector for update 11.If you are on ColdFusion 10 Update 5 or later and have not re-installed/reconfigured the connector earlier then you will have to re-install/reconfigure the connector for update 11.