Important update: Note that ColdFusion 10 and 11 have been updated to support Windows 10, a couple months after this blog post was first written. Consider applying that update rather than this manual configuration.
With Windows 10 out, there is a problem that most of the ColdFusion customers will face, configuring connectors for IIS 10. Wsconfig, the connector configuration tool, only supports till IIS 8.x. While the ColdFusion team is working on this issue and will try to provide the fix for it as soon as possible, there is already a KB article which can be referred for configuring the connectors manually. Although the article was originally written for CF10, it can be used for CF11 also. After following all the steps in the article, you need to do one more thing. Add index.cfm as default document for your website in IIS.
This solution is only recommended for development environments as thorough testing of the connectors with IIS 10 is still going on. So for production machines, you should wait for the actual release from Adobe.